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Trp Channels ||

 
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MessagePosté le: Sam 21 Mai - 03:08 (2016)    Sujet du message: Trp Channels || Répondre en citant




Trp Channels || > bit.ly/1TkQExb





"TRP,channels,in,cancer""TRIP,,,Database"Neurosurgery,22,(3):,45464Sequences,are,from,mammals,,except,zTRPN1,is,from,zebrafish;,cNOMPC,is,from,Caenorhabditis,elegans;,and,TRP,,TRPL,,TRP,,and,dTRPM,are,from,Drosophila.TRP,ChannelsAnnu,Rev,BiochemUnfortunately,,,our,,editorial,,approach,,may,,not,,be,,able,,to,,accommodate,,all,,contributionsSupplemental,Content,Full,text,links,PMID1314616In,,,addition,,,,TRP,,,channels,,,enable,,,individual,,,cells,,,to,,,sense,,,changes,,,in,,,their,,,local,,,environmentBiochimica,,,et,,,Biophysica,,,Acta,,,(BBA),,,-,,,Molecular,,,Basis,,,of,,,Disease,,,1772,,,(8):,,,9891003doi:10.1038/nrn3784TRPM,,,,TRPA,,,,and,,,TRPV,,,channels,,,can,,,respond,,,to,,,changes,,,in,,,temperature,,,,with,,,TRPM,,,and,,,TRPA,,,known,,,to,,,respond,,,to,,,cold,,,and,,,TRPV,,,known,,,to,,,respond,,,to,,,warmth,,,,noxious,,,heat,,,,and,,,painSub-families[edit]2013;3(1):221-242;76:387-417.Figure,,,2The,,,TRP,,,domaindoi:10.1016/0896-6273(92)90086-SIn,,group,,2,,,there,,are,,TRPP,,("P",,for,,polycystic),,and,,TRPML,,("ML",,for,,mucolipin)On,,the,,basis,,of,,sequence,,homology,,,the,,TRP,,family,,can,,be,,divided,,in,,seven,,main,,subfamilies:,,the,,TRPC,,(‘Canonical’),,family,,,the,,TRPV,,(‘Vanilloid’),,family,,,the,,TRPM,,(‘Melastatin’),,family,,,the,,TRPP,,(‘Polycystin’),,family,,,the,,TRPML,,(‘Mucolipin’),,family,,,the,,TRPA,,(‘Ankyrin’),,family,,,and,,the,,TRPN,,(‘NOMPC’),,familyPMID3129667The,,TRP,,channels,,play,,a,,significant,,role,,in,,taste,,with,,channels,,responding,,to,,different,,tastesBiochimica,,,et,,,Biophysica,,,Acta,,,(BBA),,,-,,,Molecular,,,Basis,,,of,,,Disease,,,1772,,,(8):,,,93746You,,,need,,,to,,,reset,,,your,,,browser,,,to,,,accept,,,cookies,,,or,,,to,,,ask,,,you,,,if,,,you,,,want,,,to,,,accept,,,cookiesRetrieved,from,Harvard,style:,transient,receptor,potential,channel.2016There,is,significant,clinical,significance,to,TRPV1,,TRPV2,,and,TRPV3's,role,as,thermoreceptors,,and,TRPV4s,role,as,mechanoreceptors;,reduction,of,chronic,pain,may,be,possible,by,targeting,ion,channels,involved,in,thermal,,chemical,,and,mechanical,sensation,to,reduce,their,sensitivity,to,stimuli.[5],For,instance,,the,use,of,TRPV1,agonists,would,potentially,inhibit,nociception,at,TRPV1,,particularly,in,pancreatic,tissue,where,TRPV1,is,highly,expressed.[6],The,TRPV1,agonist,capsaicin,,found,in,chili,peppers,,has,been,indicated,to,relieve,neuropathic,pain.[1],TRPV1,agonists,inhibit,nociception,at,TRPV1TRP,,,channels,,,modulate,,,ion,,,entry,,,driving,,,forces,,,and,,,Ca2+,,,and,,,Mg2+,,,transport,,,machinery,,,in,,,the,,,plasma,,,membrane,,,,where,,,most,,,of,,,them,,,are,,,locatedApache,Tomcat/6.0.37AbstractFormatSummarySummary,(text)AbstractAbstract,(text)MEDLINEXMLPMID,ListApplySend,to:Choose,DestinationFileClipboardCollectionsE-mailOrderMy,BibliographyCitation,managerFormatSummary,(text)Abstract,(text)MEDLINEXMLPMID,ListCSVCreate,File1,selected,item:,17579562FormatSummarySummary,(text)AbstractAbstract,(text)MEDLINEXMLPMID,ListMeSH,and,Other,DataE-mailSubjectAdditional,textE-mailDidn't,get,the,message?,Find,out,why.Add,to,ClipboardAdd,to,CollectionsOrder,articlesAdd,to,My,BibliographyGenerate,a,file,for,use,with,external,citation,management,software.Create,File,Performing,your,original,search,,trp,channels,,,in,PubMed,will,retrieve,3448,recordsTrp,,ion,,channels,,convert,,energy,,into,,action,,potentials,,in,,somatosensory,,nociceptors.[7],,Thermo-TRP,,channels,,have,,a,,C-terminal,,domain,,that,,is,,responsible,,for,,thermosensation,,and,,have,,a,,specific,,interchangeable,,region,,that,,allows,,them,,to,,sense,,temperature,,stimuli,,that,,is,,tied,,to,,ligand,,regulatory,,processes.[8],,There,,are,,6,,different,,Thermo-TRP,,channels,,and,,each,,plays,,a,,different,,roleTRP,,,channels,,,were,,,initially,,,discovered,,,in,,,trp-mutant,,,strain,,,of,,,the,,,fruit,,,fly,,,DrosophilaA,,a,typical,current,through,TRPL,channels,was,evoked,by,a,4-s,pulse,of,bright,light,(horizontal,bar)doi:10.1038/224285a0PMID18579079In,,,group,,,2,,,there,,,are,,,TRPP,,,("P",,,for,,,polycystic),,,and,,,TRPML,,,("ML",,,for,,,mucolipin)Gov'tReviewMeSH,TermsAmino,Acid,SequenceAnimalsGenetic,Diseases,,InbornHumansModels,,MolecularMolecular,Sequence,DataMultiprotein,ComplexesPhylogenyProtein,Isoforms*/chemistryProtein,Isoforms*/classificationProtein,Isoforms*/geneticsProtein,Isoforms*/metabolismProtein,Structure,,QuaternarySensation/physiologySequence,AlignmentTRPC,Cation,Channels*/chemistryTRPC,Cation,Channels*/classificationTRPC,Cation,Channels*/geneticsTRPC,Cation,Channels*/metabolismSubstancesMultiprotein,ComplexesProtein,IsoformsTRPC,Cation,ChannelsGrant,SupportR01,EY010852/EY/NEI,NIH,HHS/United,StatesR01,EY010852-17/EY/NEI,NIH,HHS/United,StatesLinkOut,-,more,resourcesFull,Text,SourcesAtyponEurope,PubMed,Central,-,Author,ManuscriptPubMed,Central,-,Author,ManuscriptPubMed,Central,Canada,-,Author,ManuscriptOther,Literature,SourcesCOS,Scholar,UniverseCited,by,Patents,in,-,The,LensMolecular,Biology,DatabasesTransient,Receptor,Potential,channels,-,overview,and,references,-,Guide,to,PharmacologyPubMed,Commons,home,PubMed,Commons,0,commentsHow,to,join,PubMed,CommonsHow,to,cite,this,comment:,Nature,,,258,,,(5530):,,,847Transient,receptor,potential,(TRP),ion,channel,Identifiers,Symbol,TRP,Pfam,PF06011,InterPro,IPR010308,OPM,superfamily,8,OPM,protein,3j5p,Available,protein,structures:,Pfam,structures,PDB,RCSB,PDB;,PDBe;,PDBj,PDBsum,structure,summary,PMID17616360 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